Update: Proposal Concluded & Withdrawn
The technical and computational bottlenecks outlined in this pitch have been successfully bypassed independently. The final phase of the ISB framework—including the 5th expansion (RNA velocity kinetics)—is now fully integrated, and the SDE-PDE simulation has been scaled and executed across a mega-cohort of N=100,000 virtual subjects.
The comprehensive final manuscript is complete, and the entire production pipeline is permanently secured open-source on Zenodo and GitHub. External funding is no longer required.