Reasonable! Signed
@AaronSilverbook
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Comments
Aaron Silverbook
4 months ago
BCS3L1 secretes 0.032 grams of ethanol over 24 hours. A shot of vodka is about 12 grams of ethanol.
I strongly doubt it'll make anyone fail a breathalyzer, but I'll let you know once I've put it in my mouth.
Aaron Silverbook
5 months ago
(See the safety review section, "How might this disrupt the microbiome", subheading, "In the gut"
Aaron Silverbook
5 months ago
@7b7599c6-0cb1-4473-8d5b-d4687cc16b39
Oh, the odds of it successfully colonizing the gut seem very low to me. Humans are constantly swallowing wild S mutans without issue, so I don't expect it to gain a foothold on its own. The mutacin 1140 could be an issue, but mutacin isn't very stable through the stomach acid, and the half-life/pharmokinetics are pretty bad; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256755/.
BCS3L1 contains JH1140's knockouts for genetic stability, too, so I expect it to mutate much less than standard S mutans. A year of rat testing didn't indicate disruption to their gut microbiota.
Additionally, the people who self-colonized with strains like JH1005 haven't reported any issue ¯\_(ツ)_/¯
If everyone on earth colonized with this, I suppose I do expect someone to get autobrewery, because multiplying a very small number by a very big number does yield a number, but I don't expect to see that failure state in the first million people.
Aaron Silverbook
5 months ago
Technically speaking, it probably does raise the risk some, but I don't actually predict it to be a problem; see the Safety Review section "Will I get drunk?"
Aaron Silverbook
5 months ago
We can 100% accept SAFEs. We actually just opened fundraising; you can reach out at aaron@lanternbioworks.com or through our website, lanternbioworks.com
I think our odds are very good. I'm working with the original inventors, Drs. Hillman and Smith, who made it the first time.
I'm not sure that I can link to my Lightspeed application? The link they sent me is an edit link, and I don't want to post that on the public internet.